Cimentos endodônticos experimentais contendo vidros bioativos 45S5 ou niobofosfato: Biocompatibilidade bioatividade, propriedades físicas químicas e biológicas

Abstract

To evaluate the influence of bioactive particles of niophosphate glass (NbG) or 45S5 on the physicochemical and biological properties of two experimental endodontic sealers through the following tests: Setting time (initial and final), radiopacity, flow, pH change in acidic (pH=4) and neutral (pH=7) environments, mass change (sorption and solubility), bioactivity by (SEM/EDS, FTIR/ATR and DR-X); and biocompatibility by cell viability. The results were compared with each other and with different commercial sealers based on epoxy resin (AH Plus), OZE (Endofill), and bioceramics (MTA Fillapex, EndoSequence). The data were analyzed by one-way ANOVA and Holm-Sidak post-test (α=5%), Kruskal-Wallis test and Students-Newman-Keuls post-test (α=5%). The experimental cements containing 45S5 and NbG in their physicochemical properties showed great loss and change in mass. The cement composed of 45S5 did not show radiopacity. AH Plus presented the highest cell viability values ​​followed by 45S5; NbG; MTA; BC Sealer and Endofill. SEM/EDS analysis identified precipitates with high concentrations of Ca/P in the 45S5 and NbG cements, as well as in MTA Fillapex, BC Sealer, with the exception of AH Plus and Endofill. FTIR/ATR and XRD analyses showed that the two experimental sealers and the commercial sealers MTA Fillapex and BC Sealer presented hydroxyapatite precursor peaks. The bioactive groups demonstrated alkalinization of the medium. Based on the evidence, it is concluded that the use of bioactive fillers in endodontic sealers is promising, since they did not negatively influence the physicochemical and biological properties of the experimental endodontic sealers.